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ketofirm forskolin or Forskolin is a chemical found in the roots of Coleus forskohlii, an Indian Coleus plant. It was first studied in 1974 by scientists from Central Drug Research Institute of India and Hoechst India in screening programs that examined medicinal plants mainly for cardiovascular activity. Apart from being used to raise cyclic AMP (cAMP) levels in study and research of cell philosophy, Forskolin has been used since ancient times to treat high blood pressure, heart disorders and angina and at times respiratory disorders like asthma. Coming back to cell research, Coleonol activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP thereby re-sensitizing cell receptors.
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