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DHEA is the most plentiful hormone in the human body, but its production declines with age. As the levels of DHEA decrease, so does this important metabolite, 7-KETO. The levels of DHEA and its numerous derivatives, manufactured in the adrenal glands, begin to decline after the age of 30 with about a 50% decline by the age of 40 and about 85% decline by the age of 70. As these hormone levels decline during the aging process, there are some detrimental physiological and anatomical effects which occur as a result. These include a reduction in protein biosynthesis which lead to a loss in muscle mass, and reduction in bone tissue regeneration which causes a loss of bone mass (a risk factor for osteoporosis). Other effects include the decline in the metabolic rate which causes an increase in fat accumulation, a decline in various immune system functions, and an increased rate of memory loss.