ADC drug development

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Genemedi

https://www.genemedi.net/i/what-is-anti-dm1-dm4-antibody

The use of anti-DM1/DM4 antibodies in pharmacokinetic (PK) studies is crucial for understanding the behavior of Antibody-Drug Conjugates (ADCs) that utilize DM1 or DM4 as their cytotoxic payloads. DM1 (maytansinoid DM1) and DM4 (maytansinoid DM4) are potent microtubule inhibitors used in ADCs to target and kill cancer cells. Here's why and how anti-DM1/DM4 antibodies are used in PK studies.

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