Ivy Young

MGF, 2mg/vial

Sequence: Tyr - Gln - Pro - Pro - Ser - Thr - Asn - Lys - Asn - Thr - Lys - Ser - Gln - D - Arg - D - Arg - Lys - Gly - Ser - Thr - Phe - Glu - Glu - His - Lys - NH2

M.W: 2848.13

Solubility: Insoluble in water. Dissolve peptide in 50-100 µl of 60% Acetonitrile in water or DMSO, then dilute with any desired buffer.

Storage Condition: Store peptide in DRY form at 0-5°C.

Appearance: White powder

Content: The contents of this vial have been accurately determined to contain 100µg of NET peptide.

HPLC Analysis Purity =95%

Action:When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the up regulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle. MGF is available as an inject able peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

Mechano Growth Factor is a peptide hormone, a natural physiological byproduct created in a human body as a result of an exercise. Mechano Growth Factor (MGF) and IGF-1 (Insulin-like Growth Factor) are isoforms. Isoform is a protein with a slightly different form but usually a similar function as its ‘fellow’ isoform protein. Both, MGF (which is a liver derived hormone) and IGF-1 (which is produced in the muscles) have anabolic effects, but the anabolic powers of the MGF are greater than those of IGF-1. Anabolic quality of a substance is such that increases the levels of synthesis, either at a molecular or a cellular level, meaning the Mechano Growth Factor has a greater sensitivity to damages caused to muscles by exercise and induces the synthesis of a greater amount of proteins in skeletal muscles.

Another favorable effect of the Mechano Growth Factor is its ability to activate the satellite cells of muscles (myosatellite cells). Myosatellite cells behave as stem cells. Once they are activated they fuse, form myoblastst, proceed to differentiate and form entirely new muscle cells. Again, the result is muscle growth.