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Fildena
100 is a medicine that helps to treat erectile dysfunction. It works by
inhibiting the PDE5 enzyme. This helps to increase blood flow to the erectile
tissue, which improves erection.
PDE5 inhibitors are the primary
treatment for erectile dysfunction (ED). They help to increase blood flow to
the penis and to stimulate erection. They are also effective in treating
pulmonary hypertension and heart disease.
The most common PDE5 inhibitors
include sildenafil, tadalafil, vardenafil, and avanafil. Each drug acts on a different
phosphodiesterase responsible for metabolizing cyclic guanosine monophosphate
(cGMP).
Sildenafil and tadalafil are the
most commonly prescribed PDE5 inhibitors for treating ED. They act on the
phosphodiesterase type 5 (PDE5) enzyme to prevent the conversion of GTP into
cGMP. This causes the body to release nitric oxide (NO) from nerve terminals
and endothelial cells in the corpus cavernosum, which led to smooth muscle
relaxation and increased blood flow to the penis.
Another type of PDE5 inhibitor,
vardenafil, also works on the phosphodiesterase type 5 enzyme but does affect
NO levels in the body. This is because vardenafil does not contain NO.
Vardenafil has a prolonged action
period, lasting for 24 to 36 hours. It can be taken daily in doses of 2.5 to 20
mg. It is most commonly used for the treatment of ED but can also be used to
treat other conditions, such as pulmonary arterial hypertension and prostate
cancer.
Although vardenafil is the
longest-acting PDE5 inhibitor, it has the highest risk of side effects.
Therefore, it should be used only after consulting a doctor.
The effectiveness of sildenafil,
tadalafil, and vardenafil depends on their concentrations in the bloodstream.
Several factors can affect these concentrations, including drug interactions,
diseases, and other conditions.
Some of these medications can
interact with a drug called cytochrome 450 (CYP) inhibitors, mainly used to
control the number of certain medicines in the body. Some of these drugs may
increase the amount of PDE5 inhibitors in the bloodstream and can also reduce
their efficacy.
Other medications affecting the
blood concentrations of PDE5 inhibitors include erythromycin, ketoconazole, and
itraconazole. These drugs may also interfere with the metabolism of these
drugs, which can lead to higher drug concentrations and increased risk of side
effects.
Because of this, you are closely
monitoring your medication, and monitoring your blood levels is essential. If
you notice that your blood level of a drug is getting low, talk to your doctor
right away.
The most common side effects of
PDE5 inhibitors are headaches, indigestion, and diarrhea. These side effects
can be uncomfortable and may even require medical attention. However, they
usually pass quickly after treatment. Other side effects can include fatigue,
dizziness, and rash. If you experience these symptoms, stop taking medicine and
contact your doctor.
Other Info: Fildena
150