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Tramadol is a unique compound with both a moderate mu-opioid effect (when compared to classic opioids) and a moderate monoaminergic effect (when compared to tricyclic antidepressants). Tramadol has a more acceptable side-effect profile in comparison with tricyclic antidepressants and antiepileptics. Although possible, tolerance and dependence pose uncommon complications of the treatment. Out of the four main pain types, the action of Tramadol is not limited to neuropathic pain only but also includes suppression of noxious (nociceptive) pains.

Classification of Tramadol-Manageable Pain Types
Neuropathic pain arises spontaneously or regularly from damaged nerves. The neural signals behind neuropathic pain are unlike those channeled from damaged tissue (which can appear as the result of a fall, a cut or a burn) along healthy nerves. This type of pain requires special medications known as painkillers; it not infrequently ensues from spinal cord injuries, amputated limbs (phantom pains) and postherpetic conditions.
Opioid painkillers, such as Tramadol and morphine, often come in handy for neuropathic cases. With similar efficiency, the above drugs also work for nociceptive pains, which constitute a normal response of organs/tissues to noxious injuries. This latter type includes musculoskeletal and visceral pain cases. Sometimes, sources of noxious pain can be localized (such as joint pain or cutaneous injuries); in other cases, the pain may be referred to organs or internal tissues.